Parabacteroides goldsteinii-derived outer membrane vesicles alleviate acute lung injury via modulation of bile acid metabolism - PubMed
3 hours ago
- #bile acid metabolism
- #gut-lung axis
- #acute lung injury
- Parabacteroides goldsteinii-derived outer membrane vesicles (Pg-OMVs) alleviate acute lung injury (ALI) by modulating bile acid metabolism.
- Pg-OMVs reduce inflammatory cell infiltration and pro-inflammatory cytokines in a bleomycin-induced ALI mouse model.
- Treatment with Pg-OMVs alters gut microbiota, increasing Akkermansia muciniphila and decreasing Clostridia_bacterium.
- Fecal microbiota transplantation (FMT) confirms the gut-lung axis mediates Pg-OMVs' protective effects.
- Pg-OMVs elevate cholic acid (CA) levels, which suppress macrophage pyroptosis via NF-κB pathway inhibition.
- Pharmacological inhibition of CA reverses the protective effects of Pg-OMVs, highlighting its critical role.
- Findings suggest a novel therapeutic strategy for ALI/ARDS by targeting the gut-lung axis.