Conductive coordination nanozyme prodrugs precisely trigger pyroptosis, cuproptosis and ferroptosis for in situ cancer vaccination - PubMed
4 hours ago
- #pyroptosis
- #nanozymes
- #cancer immunotherapy
- Conductive coordination nanozyme prodrugs (Cu-DHN) trigger pyroptosis, cuproptosis, and ferroptosis for in situ cancer vaccination.
- Cu-DHN's π-conjugated polyphenol backbone acts as an 'electron highway,' enhancing peroxidase-like activity for efficient catalysis.
- The prodrug remains inert in circulation but is activated in the tumor microenvironment via GSH-depletion and H2O2-responsive logic gates.
- Activation leads to a self-cascade reaction, transforming Cu-DHN into juglone, which induces pyroptosis and cuproptosis.
- This process elicits immunogenic cell death and systemic antitumor immunity, suppressing primary and metastatic tumors with a high safety profile.