Chloroquine, an Anti-Malaria Drug as Effective Prevention for Hantavirus (2021)

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Chloroquine showed antiviral activity against multiple hantaviruses in vitro with an IC50 of about 10.2 μM and a selectivity index of 25.5.
In newborn C57BL/6 mice infected with Hantaan virus, chloroquine treatment of mothers led to dose-dependent survival rates, with 72.7% survival at 10 mg/kg.
In the Syrian hamster model for Andes virus, subcutaneous chloroquine via osmotic pump resulted in 60% survival prophylactically and delayed disease therapeutically.
Chloroquine's efficacy varied by administration route; intraperitoneal high doses showed toxicity, while slow-release osmotic pumps improved outcomes.
Chloroquine is proposed as a potential prophylactic for hantavirus infections due to its safety profile, availability, and low cost.

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