Morphine Plus Placebo vs Morphine Plus Acetaminophen for Acute Pain in the Emergency Department: A Randomized Clinical Trial - PubMed
3 hours ago
- #pain management
- #clinical trial
- #emergency medicine
- Study compares morphine plus placebo vs morphine plus acetaminophen for acute pain in emergency departments (EDs).
- Multicenter, double-blind, randomized, placebo-controlled noninferiority clinical trial conducted in 11 French EDs.
- Participants were adults (≥18 years) with severe acute pain (NRS score ≥5).
- Primary outcome: mean change in NRS pain score from baseline to 30 minutes.
- Noninferiority margin set at 1 point.
- Results show morphine plus placebo did not meet noninferiority criterion compared to morphine plus acetaminophen.
- Acetaminophen may have potential benefit as an adjunct to morphine for acute pain in EDs.