Asperuloside-Mediated Activation of Nrf2 Inhibits the NF-κB Pathway and Suppresses Osteoarthritis Progression - PubMed
7 hours ago
- #asperuloside
- #Nrf2
- #osteoarthritis
- Asperuloside (ASP) shows potential in treating osteoarthritis (OA) by activating the Nrf2 pathway and inhibiting NF-κB signaling.
- ASP reverses IL-1β-induced extracellular matrix (ECM) degradation, inflammation, and chondrocyte apoptosis in vitro.
- In a rat model of OA (DMM), ASP attenuates cartilage degeneration and suppresses oxidative stress via Nrf2/HO-1/NQO1 pathway.
- ASP's therapeutic effects include reducing inflammatory responses, ECM degradation, and chondrocyte apoptosis in both cellular and animal models.
- The study suggests ASP could be a promising disease-modifying drug for OA.