Integrated transcriptomics and molecular docking identify hub genes and statin regulators in Helicobacter pylori-associated gastric mucosal pathogenesis - PubMed
4 hours ago
- #Molecular docking
- #Helicobacter pylori
- #Gastric cancer
- Helicobacter pylori (H. pylori) infection damages gastric mucosa, leading to chronic gastritis, peptic ulcers, and gastric cancer.
- Study identified 107 co-expressed differentially expressed genes (DEGs) in vitro and in vivo, with 20 hub genes prioritized, including TNF, CXCL8, NFKBIA, and others.
- Hub genes were enriched in NF-κB, TNF, and IL-17 signaling pathways, responding to bacterial pathogens or lipopolysaccharide.
- Identified 9 upregulated transcription factors (TFs) like VDR, STAT1, and MYC, and 4 downregulated TFs including ING4 and HSF1.
- Molecular docking predicted potential therapeutic interventions with statins (Simvastatin, Atorvastatin) and TPCA-1 targeting specific hub genes.
- Findings provide a theoretical foundation for understanding H. pylori-related disease mechanisms and potential treatments.