Determinants of Circulating Tumor HPV DNA in Surgically Treated Oropharyngeal Cancer - PubMed
19 hours ago
- #Oropharyngeal Cancer
- #ctHPVDNA
- #Biomarker
- Higher estimated glomerular filtration rate (eGFR) and higher pathologic N stage were associated with higher preoperative ctHPVDNA levels.
- Perineural invasion (PNI) and pathologic extranodal extension (pENE) were associated with lower preoperative ctHPVDNA levels.
- Detectable postoperative ctHPVDNA was linked to factors like >4 positive lymph nodes, higher preoperative ctHPVDNA levels, PNI, and pENE.
- Recurrence rates were 20.0% in patients with detectable postoperative ctHPVDNA and 13.6% in those with undetectable ctHPVDNA.
- Some recurrences in patients with undetectable ctHPVDNA occurred due to refusal of guideline-concordant adjuvant therapy.