Hsa_circ_0000711 can serve as a novel biomarker for primary biliary cholangitis by promoting disease progression through the regulation of miR-185-5p and NFATc3 - PubMed
6 hours ago
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- #PBC
- #biomarker
- Hsa_circ_0000711 is significantly elevated in serum of primary biliary cholangitis (PBC) patients compared to healthy controls and other liver disease groups.
- It promotes PBC progression by acting as a sponge for miR-185-5p, which relieves repression of NFATc3, leading to increased expression of PDC-E2 and NFATc3, and worsening bile duct epithelial cell injury.
- Overexpression of hsa_circ_0000711 exacerbates cellular injury in a PBC cell model, while knockdown reverses these effects, highlighting its potential as a diagnostic biomarker and therapeutic target for PBC.