Modulating tumor-associated macrophages through APP-CD74 blockade with IL4R-exosomes synergizes with PD-1 inhibition in gastric cancer - PubMed
3 hours ago
- #tumor-associated macrophages
- #gastric cancer
- #immunotherapy
- Identifies APP-CD74 signaling axis as key driver of M2-like tumor-associated macrophage (TAM) polarization in gastric cancer, contributing to immunosuppressive microenvironment.
- Engineered IL4R-targeting exosomes loaded with APP-specific siRNA [IL4R-Exo(siCD74)] effectively target M2 macrophages and repolarize them to M1 phenotype in orthotopic models.
- Combination of IL4R-Exo(siCD74) with PD-1 inhibitor Nivolumab synergistically enhances antitumor immunity and suppresses tumor growth by reshaping immunosuppressive TME.