Kinetics of antibodies and risk of respiratory syncytial virus infection: a longitudinal cohort in Taizhou City, eastern China - PubMed

12 hours ago

Study on kinetics of antibodies and risk of RSV infection in Taizhou City, China.
Longitudinal cohort study with blood samples collected at baseline and four follow-up visits.
Two RSV epidemic waves observed: May-November 2023 and February-May 2024.
Seasonal RSV infection rates estimated at 4-7% in the community-based population.
Post-infection immunity strongest in young children (≤5 years) and weakest in adults (≥75 years).
Post-infection antibody titres declined substantially, with fourfold rises sustained for ~128 days.
PreF antibody titres' predictive performance as correlates of protection varied by age.
Age-related differences in durability and protective value of RSV PreF antibody responses highlighted.
Ethics approval obtained from Zhejiang Province CDC and Fudan University.
No competing interests declared by authors.

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