The dual roles of natural killer cells in liver immunity and tolerance: Implications for health and disease - PubMed
7 hours ago
- #liver immunity
- #NK cells
- #chronic liver disease
- The liver plays dual roles in immune defense and tolerance.
- Natural killer (NK) cells are key hepatic lymphocytes with varied functions.
- NK cells are involved in immune surveillance, tissue homeostasis, and defense against pathogens and tumors.
- NK cell activation is regulated by a balance of activating and inhibitory receptors.
- NK cells participate in antiviral responses, tumor surveillance, fibrosis regulation, and liver regeneration.
- In chronic liver diseases, NK cell dysfunction contributes to disease progression.
- Emerging therapies like CAR-NK cells and cytokine-based treatments aim to restore NK cell functionality.
- NK cells are significant in immune regulation, disease progression, and therapeutic innovation.