Evaluation of Artemisia annua-Scutellaria baicalensis Herb Pair Carbon Dots Interfering NLRP3 Inflammatory Pathway For Effective Against H1N1 Viral Pneumonia in Mice Model - PubMed
4 hours ago
- #NLRP3 inflammasome
- #viral pneumonia
- #Traditional Chinese Medicine
- Study evaluates Artemisia annua-Scutellaria baicalensis herb pair carbon dots (QH-CDs) for treating H1N1 viral pneumonia in mice.
- QH-CDs significantly reduced lung tissue damage, lung index, and promoted body weight recovery in infected mice.
- Treatment with QH-CDs decreased inflammatory cytokines (IL-1β, IL-6) by over 60% and reduced lung viral titers by more than 70%.
- Transcriptomic analysis showed QH-CDs reversed gene expression changes related to immunity and inflammation, particularly in the NLRP3 inflammasome pathway.
- QH-CDs demonstrated combined antiviral and anti-inflammatory effects, suggesting potential for treating viral pneumonia.