AND logic nanoparticle for precision immunotherapy of metastatic cancers - PubMed
12 hours ago
- #immunotherapy
- #metastatic cancer
- #nanoparticle
- AND-gated nanoparticle activates STING pathway for immunotherapy of metastatic cancers.
- Requires acidic pH and hypoxia signals to differentiate tumour from normal tissues.
- Reduces metastatic burdens in immune-cold tumour models with minimal systemic toxicity.
- STING activation in type I dendritic cells drives CD8+ T cell priming and infiltration.
- Synergizes with immune checkpoint inhibitors for enhanced efficacy.
- Offers a safe and effective therapeutic approach for metastatic cancers.