Tribbles Pseudokinases in Cardiovascular Diseases: Molecular Mechanisms, Genetic Insights, and Therapeutic Prospects - PubMed
4 hours ago
- #Therapeutic Targets
- #Tribbles Pseudokinases
- #Cardiovascular Disease
- Cardiovascular disease (CVD) is a major global health challenge with high incidence and mortality rates.
- Tribbles family proteins (TRIB1, TRIB2, TRIB3) play a key role in CVD pathogenesis, including coronary heart disease, heart failure, and hypertension.
- These proteins regulate mechanisms like inflammatory responses, apoptosis, endoplasmic reticulum stress, and insulin signaling pathways.
- Genetic polymorphisms in tribbles family genes are linked to CVD susceptibility and disease risk.
- Therapeutic strategies targeting tribbles proteins show potential for improving cardiac and vascular function.
- The review discusses tribbles protein structures, their mechanisms in CVD, and their potential as therapeutic targets.