Streptococcus anginosus-generated succinate promotes the progression of gastric cancer via the succinate/SUCNR1/ABRAXAS1 axis - PubMed
3 hours ago
- #Streptococcus anginosus
- #succinate
- #gastric cancer
- Streptococcus anginosus (S. anginosus) is linked to gastric cancer progression.
- High abundance of S. anginosus correlates with poor prognosis in gastric cancer.
- S. anginosus and its conditioned medium (S. a CM) promote cancer cell proliferation, invasion, and migration.
- Succinate, a metabolite from S. anginosus, is identified as a key factor in gastric carcinogenesis.
- Knockdown or inhibition of the succinate receptor SUCNR1 blocks the tumor-promoting effects of succinate.
- S. anginosus-derived succinate binds to SUCNR1, activating the PI3K/AKT pathway via interaction with ABRAXAS1.