The putative role of the microbiota in the development of neuropsychiatric disorders following early childhood malnutrition - PubMed
3 hours ago
- #microbiota
- #malnutrition
- #neurodevelopment
- Early childhood malnutrition (ECM) is linked to increased risk of cognitive impairment and neuropsychiatric disorders.
- ECM is associated with delayed maturation and reduced diversity of the intestinal microbiota.
- Microbial alterations coincide with metabolic, immune, and barrier dysfunctions affecting brain development.
- Animal studies show microbiota perturbation during early periods can cause lasting neurodevelopmental changes.
- Future research needs longitudinal studies and interventions to test microbiota restoration's impact on neurodevelopment.
- Understanding these relationships could help mitigate long-term effects of early nutritional adversity.