The dual roles of microorganisms in inflammatory diseases: initiators and regulators - PubMed
3 hours ago
- #inflammation
- #microbiome
- #immunology
- The microbiome influences inflammatory responses and homeostasis via metabolites, structural signals, and immune interactions.
- Dysbiosis can lead to persistent inflammation, while some commensal microbes and their metabolites can suppress excessive immune responses.
- Microbiome acts as a central node that both initiates and regulates inflammatory networks in diseases.
- Multi-omics studies reveal systemic cross-organ axes (e.g., gut-brain, gut-liver) that integrate inflammation and immunity.
- Inflammation is reframed as an adaptive strategy for systemic stability, not just a pathological reaction.
- Therapies like FMT, engineered microbes, and metabolic interventions are advancing precision microecological medicine.
- Systems biology and spatial omics are shifting research from descriptive to mechanistic control of the microbiome.
- This represents a paradigm shift from suppressing inflammation to reconstructing ecological order in medicine.