Fitness beyond age: Multidisciplinary expert opinion on redefining fitness for targeted therapies in chronic lymphocytic leukemia - PubMed
5 hours ago
- #chronic lymphocytic leukemia
- #patient fitness
- #targeted therapies
- Advancements in chronic lymphocytic leukemia (CLL) have led to novel targeted therapies.
- Patient fitness for treatment traditionally based on chemoimmunotherapy tolerability, with age as a major factor.
- Fitness assessment should consider polypharmacy, infections, comorbidities, functional status, cognitive/psychological status, nutritional status, and social support.
- Assessment flow includes clinical evaluation, geriatric/cardiovascular/renal reviews, and patient history to evaluate treatment risks.
- Cardiovascular risk ranges from low to high; high-risk patients should collaborate with a cardiologist.
- Geriatric assessment helps determine frailty, resilience, and avoid inappropriate treatment based on age.
- Continuous monitoring and assessment are recommended regardless of therapy.
- Patient preferences are integral to treatment decision-making.
- Treatment selection should focus on fitness rather than chronological age in the new era of CLL care.