Outcomes of different treatment patterns for adenoid cystic carcinoma of the anterior craniofacial area: A multi-institutional study on 578 patients - PubMed
6 hours ago
- #Proton therapy
- #Adenoid cystic carcinoma
- #Craniofacial surgery
- Adenoid cystic carcinoma of the anterior craniofacial region (ACF-ACC) is difficult to treat due to subclinical spread and proximity to critical structures, with surgery followed by radiotherapy being the standard.
- The multi-institutional study of 578 patients (1984-2023) found high recurrence rates, with a 20-year local recurrence cumulative incidence of 74.1% and distant metastasis incidence of 55.6%.
- Gross total resection (GTR) followed by adjuvant radiotherapy, particularly proton therapy, provided the best local control, while R2 resections offered no advantage over non-surgical treatment.
- In non-surgical treatment cases, proton therapy resulted in higher complete response rates than photon radiotherapy, with responders showing local control similar to surgically treated patients.
- The study concluded that GTR plus modern radiotherapy is optimal for local control, R2 surgery should be avoided, and proton therapy is an effective definitive option for selected patients.