Impact of Adverse Childhood Experience on Lung Cancer Risk: A Population-Based Prospective Cohort Study - PubMed
6 hours ago
- #lung-cancer-risk
- #smoking-mediation
- #adverse-childhood-experiences
- Adverse childhood experiences (ACEs) increase lung cancer risk cumulatively, with severe adversity (≥3 types) linked to an 82% higher risk.
- Smoking mediates about 40% of the association between ACEs and lung cancer, and smoking cessation reduces risk but may be less protective in severe adversity cases.
- The study uses UK Biobank data and Cox regression models, showing that ACEs also elevate lung cancer mortality risk, highlighting the need for further research on additional pathways.