An interactome-based framework for DDB1- and CUL4-associated factor prioritization in targeted protein degradation - PubMed
4 hours ago
- #interactome analysis
- #DCAF family
- #targeted protein degradation
- Developed an interactome-based framework for prioritizing DCAF family proteins in targeted protein degradation.
- Used proximity biotinylation in HEK293T cells to systematically map interactors and functions of DCAFs.
- Identified substrates for model DCAFs COP1 and DCAF3 via multi-omics approaches.
- Proposed CRL4 complex formation and DCAF autodegradation as indicators of DCAF degradation activity.
- Provided a resource for characterizing DCAFs and guiding their use in therapeutic degradation strategies.