Mitochondrial DNA: a molecular switch driving sterile neuroinflammation - PubMed
7 days ago
- #Neuroinflammation
- #Neurodegeneration
- #Mitochondrial DNA
- Mitochondrial DNA (mtDNA) triggers innate immune responses when released into the cytoplasm or extracellular space.
- mtDNA activates the cGAS-STING pathway and Toll-like receptors, leading to pro-inflammatory cytokine production.
- This process contributes to neurodegenerative diseases like Alzheimer's, Parkinson's, and Huntington's disease.
- mtDNA serves as both a damage-associated molecular pattern and a signaling molecule.
- Potential therapeutic target for modulating neuroinflammation and protecting against neuronal damage.