Porphyromonas gingivalis Promotes Neuroinflammation by Microglial Ferroptosis via NOX4/PPAR-α/PGC-1α Pathway - PubMed
3 hours ago
- #Alzheimer's disease
- #ferroptosis
- #neuroinflammation
- Porphyromonas gingivalis (P.g) oral pathogen induces cognitive deficits, hippocampal neurodegeneration, and neuroinflammation in mice.
- P.g promotes microglial ferroptosis and mitochondrial dysfunction via the NOX4/PPAR-α/PGC-1α pathway.
- NOX4 silencing or knockout reverses ferroptosis, restores PPAR-α/PGC-1α signaling, and mitigates inflammation and cognitive impairment.
- Findings link oral health to Alzheimer's disease pathology, suggesting NOX4 as a potential therapeutic target.