Huang-Qi-Long-Dan Granule alleviates ischemic stroke injury by regulating the crosstalk between Nrf2 and NF-κB signaling - PubMed
3 hours ago
- #Nrf2-NF-κB crosstalk
- #ischemic stroke
- #herbal medicine
- Huang-Qi-Long-Dan Granule (HQLDG) is used to treat ischemic stroke (IS) and its mechanism was explored.
- HQLDG decreased brain thrombosis, improved blood flow, and regulated coagulation genes in zebrafish.
- It also ameliorated motor activity and brain pathology in tMCAO mice.
- HQLDG reduced oxidative stress, inflammation, and apoptosis in both zebrafish and mice.
- The protective effects of HQLDG were linked to Nrf2 translocation into the nucleus.
- Inhibition of Nrf2 or NF-κB reduced HQLDG's protective effects, confirming their crosstalk.
- HQLDG shows promise as a therapeutic for IS, with zebrafish complementing mammalian models.