Transient SUMOylation inhibition in human pre-adipocytes stably imprints a transcriptional beiging fate - PubMed
2 hours ago
- #Adipocyte beiging
- #Epigenetic regulation
- #SUMOylation
- Transient SUMOylation inhibition in human pre-adipocytes leads to stable beige differentiation.
- TAK-981, a SUMOylation inhibitor, combined with PPARG agonist rosiglitazone, induces beige adipocyte markers like UCP1 and enhances mitochondrial respiration.
- Mechanistic insights reveal chromatin remodeling, activation of CEBPA and PPARG networks, and loss of H3K27me3 at thermogenic enhancers.
- Enhanced cAMP-PKA-p38 signaling stabilizes beiging transcription activators, promoting adaptive thermogenesis.
- SUMOylation acts as an epigenetic barrier to adipocyte beiging, suggesting therapeutic potential for modulating adipose tissue thermogenic capacity.