Tolerogenic dendritic cells induced by withdrawal of polyunsaturated fatty acid DHA and mTOR inhibitor PP242 attenuate allograft rejection - PubMed
6 hours ago
- #Tol-DC
- #DHA
- #transplantation
- Tolerogenic dendritic cells (Tol-DCs) can be induced by withdrawing docosahexaenoic acid (DHA) and mTOR inhibitor PP242.
- Combined use of DHA and PP242 (comb-DHA) hinders DC maturation while maintaining phagocytic capabilities.
- Retained DHA in DCs facilitates delayed activation of p-AKT Ser473 and PTDSS2-related pathways, leading to Tol-DC induction.
- Comb-DHA-DCs show reduced expression of costimulatory molecules and inhibit T-cell proliferation.
- Adoptive transfer of comb-DHA-DCs suppresses allograft rejection, offering a novel therapeutic strategy for graft tolerance.