PROTAC-based synthetic lethality strategy endogenously activates systemic STING to boost antitumor immunity - PubMed
3 hours ago
- #antitumor immunity
- #PROTAC
- #STING pathway
- PROTAC-based synthetic lethality strategy activates STING pathway to enhance antitumor immunity.
- Degradation of PARP1 and BRD4 disrupts DNA repair, leading to cytosolic DNA leakage and STING activation.
- Superior antitumor efficacy observed in multiple tumor models with robust CD8+ T cell and NK cell responses.
- Strategy suppresses pulmonary metastasis progression by leveraging cGAS-STING-mediated innate immunity.
- Integration of synthetic lethality with immunogenic stress response offers a new paradigm for cancer therapy.