Estrogen receptor β deficiency increases susceptibility to sepsis through metabolic reprogramming-induced macrophage pyroptosis - PubMed
4 hours ago
- #immunology
- #sepsis
- #macrophage
- Estrogen receptor β (ERβ) deficiency increases susceptibility to sepsis.
- ERβ levels are reduced in sepsis patients and correlate with disease severity.
- ERβ deficiency induces macrophage pyroptosis, impairing bacterial clearance.
- Mechanism involves enhanced fatty acid oxidation, increased acetyl-CoA, and Stoml2 acetylation at K221.
- Mutation of Stoml2 K221 site improves survival in septic mice.
- ERβ deficiency is a potential genetic factor in sepsis susceptibility.