Nup107 is a crucial regulator of torso-mediated metamorphic transition in Drosophila melanogaster - PubMed
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- #Nup107
- #metamorphosis
- #Drosophila development
- Nup107 is essential for the metamorphic transition in Drosophila melanogaster, with its depletion leading to larval arrest.
- Nup107 depletion inhibits nuclear translocation and transcriptional activation by the ecdysone receptor (EcR), affecting Halloween genes and ecdysone biosynthesis.
- Overexpression of torso and rasV12 rescues the Nup107 depletion phenotypes, indicating Nup107's role in Torso-mediated EcR signaling.
- The study suggests Nup107's broader role in steroid hormone-dependent developmental processes, potentially analogous to puberty in humans.
- Feeding synthetic ecdysone to Nup107-depleted larvae partially restores metamorphosis, highlighting the hormone's critical role.