Spatial and single-cell transcriptomics reveals senescence-associated changes in MIA-induced ASD male mouse brain - PubMed
3 hours ago
- #autism spectrum disorder
- #senescence
- #maternal immune activation
- Study uses spatial and single-cell transcriptomics to investigate maternal immune activation (MIA)-induced autism spectrum disorder (ASD) in male mice.
- Identifies senescence-associated genes and pathways (APP-CD74, IGFBP7, CDKN1A) as key pathogenic factors in ASD development.
- Finds broad senescence-associated secretory phenotype (SASP) signatures regulated in a cell-type specific manner in MIA-induced ASD brains.
- Pharmacological inhibition of IGFBP7 and CDKN1A prevents ASD-like behaviors in MIA offspring, suggesting a potential intervention strategy.