Relationship Between Serum Melatonin Levels and Bone Mineral Density in Postmenopausal Women with Type 2 Diabetes Mellitus - PubMed
4 hours ago
- #bone mineral density
- #melatonin
- #postmenopausal women
- Study investigates serum melatonin and bone mineral density (BMD) in postmenopausal women with type 2 diabetes mellitus (T2DM).
- Melatonin levels were lower in groups with abnormal bone mass or T2DM, lowest in T2DM with abnormal bone mass.
- Melatonin positively correlates with lumbar spine and femoral neck BMD.
- T2DM mediates melatonin's effect on femoral neck BMD (33.95% of total effect), but not significantly on lumbar spine.
- ROC analysis shows melatonin level (AUC 0.942) can diagnose osteoporosis, optimal cut-off 124.29 pg/mL.
- Lower melatonin is an independent risk factor for decreased BMD in postmenopausal women with T2DM.
- Findings suggest regular melatonin monitoring may help detect early bone loss in high-risk postmenopausal women.