Prediction models for overall survival and all-cause mortality risk in older adults with cancer: a systematic review - PubMed
4 hours ago
- #geriatric-oncology
- #mortality-prediction
- #cancer
- Systematic review of prediction models for overall survival and all-cause mortality in older adults (≥65 years) with cancer.
- 250 studies included, with 72.8% reporting both model development and internal validation.
- 70.4% of models predicted overall survival; lung (16.0%) and colorectal (12.0%) cancers were most studied.
- Only 17.2% of models were specifically designed for older adults; 55.2% lacked geriatric variables (e.g., comorbidities, cognition).
- High risk of bias due to poor handling of continuous predictors, univariable selection, and overfitting issues.
- Current models are not clinically viable; future models must follow guidelines and integrate geriatric domains.