Risk factors for alloimmune lung syndromes after allogeneic hematopoietic cell transplantation in children - PubMed
7 hours ago
- #Pulmonary Complications
- #Allogeneic HCT
- #Pediatric Transplantation
- The study identified risk factors for idiopathic pneumonia syndrome (IPS) and bronchiolitis obliterans syndrome (BOS) after allogeneic hematopoietic cell transplantation in children and young adults.
- Key risk factors for IPS included non-malignant diagnosis, adenovirus reactivation, and busulfan-cyclophosphamide ± melphalan conditioning compared to other regimens.
- Busulfan-cyclophosphamide ± melphalan conditioning also increased BOS risk relative to total body irradiation and non-myeloablative regimens.
- Elevated endothelial activation and stress index (EASIX), white blood cell, and lymphocyte counts before day 100 post-transplant correlated with IPS.
- For BOS, high EASIX and increased activated or effector memory CD4+ T-cells were significant correlates, indicating distinct and overlapping risk factors for both syndromes.