Deuterosomal cells are the responsible lineage for multiciliogenesis in human airway differentiation - PubMed
4 hours ago
- #primary ciliary dyskinesia
- #multiciliogenesis
- #iPSC
- Deuterosomal cells (DCs) are crucial for multiciliogenesis in human airway differentiation.
- Multiciliated cells (MCCs) play a key role in airway defense by clearing pathogens via motile cilia.
- Primary ciliary dyskinesia (PCD) disrupts ciliary function, leading to chronic respiratory infections.
- Single-cell transcriptomics identified DCs as a transient cell population during multiciliogenesis.
- CD36 was identified as a specific surface marker for DCs using iPSC-derived airway epithelial cells.
- iPSCs from a PCD patient with CCNO variants showed defective MCC differentiation and aberrant DCs.
- The study offers a human iPSC-based platform for studying airway multiciliogenesis and PCD modeling.