Cell-free chromatin state tracing reveals disease origin and therapy responses - PubMed
3 hours ago
- #epigenetics
- #non-invasive diagnostics
- #cancer research
- Development of cf-EpiTracing, a platform for profiling histone modifications in cell-free DNA from minimal plasma volumes.
- Application of cf-EpiTracing in 2,417 profiles from healthy individuals and patients with various diseases.
- Capability to identify primary diseased tissues and organ involvement, stratify disease subtypes, and detect early-stage diseases.
- Use in monitoring disease transformation and revealing genomic and epigenetic alterations in specific cancers.
- Demonstration of cf-EpiTracing's utility in predicting recurrence risk and therapeutic response based on epigenetic signatures.
- Potential broad applications in early diagnosis, molecular subtyping, and prognostic prediction.