FUNDC1-dependent mitophagy determines axon regeneration capacity - PubMed
5 days ago
- #axon-regeneration
- #mitophagy
- #FUNDC1
- FUNDC1-mediated mitophagy is crucial for axon regeneration and peripheral nerve recovery.
- Acute nerve injury leads to impaired mitochondria accumulation and increased FUNDC1 expression.
- Overexpression of FUNDC1 enhances axonal regeneration in vitro and in vivo by maintaining healthy mitochondria.
- Urolithin A (UA), a mitophagy inducer, promotes axon regrowth post-injury.
- FUNDC1 deletion impairs regeneration, reversible by reintroducing WT FUNDC1 but not LIR mutants.
- FUNDC1-mediated mitophagy boosts carnosine biosynthesis, aiding nerve recovery via antioxidant effects.
- Sciatic nerve injury in Fundc1 TG mice upregulates NRF1 and PPARGC1A, stimulating mitochondrial biogenesis and Carns1 transcription.