Glucagon promotes net hepatic glycogen repletion following meal ingestion - PubMed
8 hours ago
- #Glucose metabolism
- #Endocrinology
- #Diabetes
- Glucagon and insulin work together to promote hepatic glycogen turnover and meal glucose storage.
- Pharmacological doses of insulin or glucagon alone do not alter hepatic glycogen, but their combination significantly reduces glycogen content.
- Coordinated insulin-glucagon signaling enhances the incorporation of dietary glucose into hepatic glycogen more effectively than glucose alone.
- Glucagon is essential for efficient hepatic glucose storage when acting with insulin, challenging the classical view of these hormones as opposing forces.