From repair to disease: lymphatic contributions to regeneration, cancer and ageing - PubMed
3 hours ago
- #lymphatic system
- #regeneration
- #ageing
- Lymphatic vasculature maintains fluid balance, lipid transport, and immune surveillance, and regulates tissue repair via lymphangiocrine signaling.
- Lymphatic endothelial cells (LECs) secrete mediators like Reelin, R-spondin-3, and CCL21 to influence stem cell niches, immunity, and regeneration.
- Age-related lymphatic dysfunction, due to LEC senescence and impaired lymphangiogenesis, leads to poor tissue repair, inflammation, and increased disease risk.
- Dysregulated lymphangiocrine signaling contributes to diseases including cancer, cardiovascular disorders, neurodegeneration, and lymphedema.
- Emerging therapeutic strategies aim to restore lymphatic function in ageing tissues to combat disease.