ACSS2 maintains oligodendrocyte progenitor cell pool and is required for myelination during development and aging - PubMed
8 hours ago
- #ACSS2
- #Myelination
- #Aging
- ACSS2 is crucial for maintaining the oligodendrocyte progenitor cell (OPC) pool and myelination during development and aging.
- Aging leads to a decline in OPCs, particularly those highly expressing Acss2, affecting myelination.
- Deletion of ACSS2 results in reduced OPC population, defective myelinogenesis, impaired myelin maintenance, and worsened age-related cognitive deficits.
- ACSS2-mediated acetylation of H4K12 and H3K27 enhances Gria2 expression, which is critical for OPC proliferation.
- Supplementation with acetate, an ACSS2 substrate, preserves OPC numbers, promotes remyelination post-injury, and improves cognitive function in aged mice.