EEPD1 evolved a unique DNA clamping dimer protecting reversed replication forks - PubMed
7 hours ago
- #cancer research
- #DNA replication
- #genome stability
- EEPD1 evolved a unique DNA clamping dimer that protects reversed replication forks.
- EEPD1 lacks nuclease activity due to loss of key catalytic residues during evolution.
- EEPD1 prevents nucleolytic degradation of reversed replication forks by MRE11.
- Structural studies reveal an unprecedented tryptophan handshake dimer and adjustable 'wrist' mechanism.
- EEPD1's function is significant in oxidative stress responses, genome stability, and cancer outcomes.