Interferon Stimulatory DNA activates the DNA damage signaling through ATM and DNA-PK sensing - PubMed
7 hours ago
- #Innate immunity
- #DNA damage response
- #cGAS-STING pathway
- Interferon Stimulatory DNA (ISD) activates DNA damage signaling through ATM and DNA-PK sensing.
- ISD stimulates the DNA damage response independently of the cGAS-STING pathway.
- Foreign DNA can promote the DNA damage response, typically triggered by genomic DNA lesions.
- ISD coordinates innate immunity and DNA damage checkpoints, two central protective functions of cells.