Nutrigenomic profiling identifies ZIP10 (SLC39A10) as a regulator of erythroid zinc homeostasis with genetic associations to anemia risk - PubMed
3 days ago
- #zinc homeostasis
- #anemia
- #nutrigenomics
- Nutrigenomic profiling identifies ZIP10 (SLC39A10) as a regulator of erythroid zinc homeostasis linked to anemia risk.
- Zinc deficiency uniquely affects heme biosynthesis and cellular maintenance in differentiating erythroid progenitors.
- ZIP10 is strongly induced by zinc deficiency and plays a compensatory role in zinc import during scarcity.
- Loss of ZIP10 exacerbates zinc depletion, reduces Alad expression, and diminishes heme output.
- SLC39A10 genetic variants are associated with hemoglobin concentration, hematocrit, and iron deficiency anemia risk.
- ZIP10 safeguards erythroid zinc homeostasis and heme synthesis under zinc-limiting conditions.
- Genetic variation in SLC39A10 may increase sensitivity to zinc deficiency, serving as a nutrigenetic marker for anemia risk.
- Findings support genotype-guided precision nutrition strategies to improve hematological health.