Immunomodulatory-osteogenic dual-functional nanofibers augment screw anchorage in osteoporotic bone - PubMed
4 hours ago
- #Osteoporosis
- #Nanofibers
- #Osseointegration
- Developed a dual-functional nanofiber scaffold (S-MS-PDA) to enhance screw fixation in osteoporotic bone.
- The scaffold uses coaxial design for spatiotemporal release of SDF-1 and P24, modulating key pathways like MAPK and Wnt to promote BMSCs recruitment and osteogenic differentiation.
- Polydopamine interface engineering improves mechanical compatibility between screw and bone, reducing stress concentration and enhancing bone-implant contact.
- In a rat osteoporosis model, the scaffold increased bone-implant contact by 3.31 fold and reduced interfacial stress.