Extracellular vesicles ameliorate intrauterine adhesion through Nrf2/GPX4-mediated ferroptosis suppression - PubMed
2 days ago
- #Intrauterine adhesion
- #Ferroptosis
- #Extracellular vesicles
- Extracellular vesicles (EVs) from Lactobacillus crispatus NCU-28 ameliorate intrauterine adhesion (IUA).
- EVs exhibit anti-inflammatory and anti-fibrotic effects by modulating the Nrf2/GPX4 signaling pathway.
- EV treatment downregulates fibrotic markers (α-SMA, TGF-β1) and pro-inflammatory cytokines (IL-6, IL-1β).
- EVs restore vaginal microbiota homeostasis and inhibit oxidative stress-induced ferroptosis.
- The study provides a basis for probiotic EV-based treatment strategies for IUA.