Clinical utility of biomarkers for outcomes prediction in adults with suspected sepsis presenting to the emergency department: a synthesis of current evidence - PubMed
8 hours ago
- #Biomarkers
- #Sepsis
- #Prognosis
- Review assessed clinical utility of biomarkers for predicting mortality or clinical deterioration in emergency department patients with suspected sepsis.
- Common biomarkers (lactate, C-reactive protein, procalcitonin) did not effectively predict adverse outcomes in meta-analyses.
- Novel biomarkers like Inflammatix Severity 2 and mid-regional proadrenomedullin showed promise, especially when combined with other biomarkers or clinical scores.
- Study limitations include heterogeneity and insufficient data for meta-analysis of novel biomarkers.
- Future research should standardize biomarker thresholds and definitions to improve comparability across studies.