The Role of Butyrate in People with Metabolic Dysfunction-Associated Steatotic Liver Disease and Related Metabolic Comorbidities: A Systematic Review - PubMed
8 hours ago
- #Butyrate
- #Gut Microbiota
- #MASLD
- Butyrate and butyrate-producing gut bacteria are linked to Metabolic dysfunction–associated steatotic liver disease (MASLD).
- Individuals with MASLD show lower fecal or serum butyrate levels and reduced abundance of butyrate-producing bacteria like Faecalibacterium prausnitzii and Eubacterium.
- Lower butyrate levels are associated with hepatic steatosis, fibrosis, inflammation, and adverse metabolic profiles such as higher BMI, insulin resistance, and dyslipidemia.
- The study highlights geographic and sex-related differences in butyrate levels and gut microbiota composition.
- Current evidence is observational, and more standardized, large-scale studies are needed to confirm findings and explore therapeutic implications.