Macrophage Gsα promotes NLRP3 stability and its intervention attenuates abdominal aortic aneurysm in male mice - PubMed
19 hours ago
- #macrophage
- #abdominal aortic aneurysm
- #NLRP3 inflammasome
- Macrophage-specific deficiency of Gsα attenuates progression of abdominal aortic aneurysm (AAA) in male mice.
- Gsα interacts with NLRP3, promoting inflammasome activation by preventing NLRP3 ubiquitination and degradation.
- Lipid nanoparticles delivering Gsα siRNA suppress NLRP3 expression and reduce AAA progression in vivo.