Rosmarinic acid alleviates ischemic stroke by targeting BAG3 to modulate autophagy via the P62-Keap1-Nrf2 pathway - PubMed
3 days ago
- #neuroprotection
- #ischemic stroke
- #autophagy
- Rosmarinic acid (RosA) targets BAG3 to modulate autophagy via the P62-Keap1-Nrf2 pathway, offering neuroprotection in ischemic stroke.
- RosA covalently binds to BAG3's Cys378 residue, disrupting its interaction with P62 and activating the P62/Keap1/Nrf2 signaling axis.
- Both in vitro (OGD/R) and in vivo (MCAO/R) models confirmed RosA's effectiveness in reducing autophagosome accumulation, infarct volume, and neurological deficits.
- BAG3 knockdown mimicked RosA's effects, confirming BAG3 as the functional target for RosA's autophagy regulation.
- The study highlights BAG3 as a promising therapeutic target for ischemic stroke intervention.