Exercise-related microRNAs in Caenorhabditis elegans regulate calcium homeostasis and mitochondrial dynamics: Conserved pathways, divergent microRNAs - PubMed
7 hours ago
- #microRNA
- #exercise biology
- #Caenorhabditis elegans
- Exercise in C. elegans improves mitochondrial content, lifespan, and fitness through a 5-day swimming regimen.
- Specific microRNAs in C. elegans (e.g., cel-miR-57-5p, cel-miR-249-3p up; cel-miR-72-3p, cel-miR-77-5p down) regulate exercise adaptations, with mutants showing changes in fertility and lifespan.
- These C. elegans microRNAs target genes involved in calcium homeostasis (e.g., ipp-5, sca-1, ncx-2) but lack direct mammalian orthologs.
- Mammalian exercise-related microRNAs (e.g., mmu-miR-181a-5p, mmu-miR-378a-3p enhance; mmu-miR-199a-5p impairs) affect mitochondrial content, autophagy, and myogenesis in murine models.
- Conserved regulatory pathways exist despite divergent microRNAs, with examples like miR-181a-5p targeting Inpp5a and miR-378a-3p targeting Ksr1/ksr-2 influencing calcium handling and MAPK signaling.