Full-length 16S rRNA nanopore sequencing enables species resolution of Fusobacterium associated with colorectal cancer - PubMed
3 hours ago
- #16S rRNA sequencing
- #Fusobacterium species
- #colorectal cancer
- Fusobacterium animalis is the primary species driving the link between Fusobacterium and colorectal cancer.
- Traditional partial 16S rRNA sequencing cannot reliably distinguish between closely related Fusobacterium species like F. animalis, F. polymorphum, and F. vincentii.
- Full-length 16S rRNA sequencing using Oxford Nanopore Technology enables accurate species-level discrimination of Fusobacterium in clinical samples.
- The method was validated using whole cells, DNA mixtures, and clinical colorectal cancer specimens, recovering expected species proportions.
- This high-resolution approach aids in elucidating species-specific roles of Fusobacterium in colorectal cancer development.